PPP1R13B

Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene.^[5][6]

PPP1R13B
Identifiers
Aliases	PPP1R13B, ASPP1, p53BP2-like, p85, protein phosphatase 1 regulatory subunit 13B
External IDs	OMIM: 606455; MGI: 1336199; HomoloGene: 9090; GeneCards: PPP1R13B; OMA:PPP1R13B - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 103,733,195 bp[1] End 103,847,575 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F1 Start 111,794,891 bp[2] End 111,874,544 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland apex of heart right hemisphere of cerebellum left testis right testis right auricle of heart left ventricle Brodmann area 10 right frontal lobe Top expressed in retinal pigment epithelium gastrula decidua otolith organ renal corpuscle utricle lacrimal gland facial motor nucleus ciliary body otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding protein binding p53 binding Cellular component plasma membrane nucleus mitochondrion nucleoplasm cytoplasm cytosol perinuclear region of cytoplasm Biological process negative regulation of cell cycle intrinsic apoptotic signaling pathway by p53 class mediator apoptotic process regulation of signal transduction by p53 class mediator regulation of apoptotic process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of neuron death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23368 21981 Ensembl ENSG00000088808 ENSMUSG00000021285 UniProt Q96KQ4 Q62415 RefSeq (mRNA) NM_015316 NM_011625 RefSeq (protein) NP_056131 NP_035755 Location (UCSC) Chr 14: 103.73 – 103.85 Mb Chr 12: 111.79 – 111.87 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.^[6]