PPP2R2A

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene.^[5]

PPP2R2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DW8
Identifiers
Aliases	PPP2R2A, B55A, B55ALPHA, PR52A, PR55A, protein phosphatase 2 regulatory subunit Balpha, PR55alpha
External IDs	OMIM: 604941; MGI: 1919228; HomoloGene: 2035; GeneCards: PPP2R2A; OMA:PPP2R2A - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 26,291,508 bp[1] End 26,372,680 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 67,251,505 bp[2] End 67,309,893 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon mucosa of esophagus oral cavity mucosa of pharynx epithelium of colon ventricular zone glutes secondary oocyte skin of leg skin of abdomen Top expressed in tail of embryo somite olfactory tubercle cumulus cell esophagus atrioventricular valve ventricular zone globus pallidus endocardial cushion superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein serine/threonine phosphatase activity protein phosphatase regulator activity protein-containing complex binding tau protein binding protein phosphatase 2A binding Cellular component nucleoplasm protein phosphatase type 2A complex cytosol synapse glutamatergic synapse Biological process response to morphine G2/M transition of mitotic cell cycle nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein dephosphorylation mitotic cell cycle peptidyl-serine dephosphorylation developmental process regulation of phosphoprotein phosphatase activity mitotic nuclear membrane reassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5520 71978 Ensembl ENSG00000221914 ENSMUSG00000022052 UniProt P63151 Q6P1F6 RefSeq (mRNA) NM_001177591 NM_002717 NM_001205188 NM_028032 NM_001360033 NM_001360034 RefSeq (protein) NP_001171062 NP_002708 NP_001192117 NP_082308 NP_001346962 NP_001346963 Location (UCSC) Chr 8: 26.29 – 26.37 Mb Chr 14: 67.25 – 67.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily.^[6]

Interactions

PPP2R2A has been shown to interact with:

• P70-S6 Kinase 1,^[7][8]
• PPP2CA,^[9][10]
• PPP2R1A,^[11][10]
• PPP2R1B,^[9][11]
• TGF beta receptor 1,^[12] and
• p107.^[13]