PPP2R5E

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.^[5][6]

PPP2R5E
Identifiers
Aliases	PPP2R5E, protein phosphatase 2 regulatory subunit B'epsilon, B56epsilon, B56E
External IDs	OMIM: 601647; MGI: 1349473; HomoloGene: 55962; GeneCards: PPP2R5E; OMA:PPP2R5E - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.2 Start 63,371,364 bp[1] End 63,543,377 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 75,497,655 bp[2] End 75,643,019 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell mucosa of ileum tibialis anterior muscle ganglionic eminence buccal mucosa cell endothelial cell deltoid muscle pericardium ventricular zone Brodmann area 23 Top expressed in Rostral migratory stream retinal pigment epithelium facial motor nucleus ciliary body human fetus hand ventromedial nucleus medial ganglionic eminence left lung lobe nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein phosphatase regulator activity protein phosphatase activator activity Cellular component protein phosphatase type 2A complex cytoplasm cytosol nucleus Biological process signal transduction regulation of phosphoprotein phosphatase activity regulation of protein autophosphorylation protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5529 26932 Ensembl ENSG00000154001 ENSMUSG00000021051 UniProt Q16537 Q61151 RefSeq (mRNA) NM_001282179 NM_001282180 NM_001282181 NM_001282182 NM_006246 NM_001354926 NM_012024 RefSeq (protein) NP_001269108 NP_001269109 NP_001269110 NP_001269111 NP_006237 NP_001341855 NP_036154 Location (UCSC) Chr 14: 63.37 – 63.54 Mb Chr 12: 75.5 – 75.64 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily.^[6]

Interactions

PPP2R5E has been shown to interact with PPP2R1B^[7] and PPP2CA.^[7][8]