PPP3CA

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA) is a protein that in humans is encoded by the PPP3CA gene.^[5][6]

PPP3CA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V
Identifiers
Aliases	PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha, IECEE, IECEE1, ACCIID, DEE91
External IDs	OMIM: 114105; MGI: 107164; HomoloGene: 55497; GeneCards: PPP3CA; OMA:PPP3CA - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 101,023,409 bp[1] End 101,348,278 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 136,375,885 bp[2] End 136,643,488 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus Region I of hippocampus proper postcentral gyrus Brodmann area 46 entorhinal cortex orbitofrontal cortex external globus pallidus pons Top expressed in olfactory tubercle hippocampus proper lateral septal nucleus globus pallidus nucleus accumbens anterior amygdaloid area lobe of cerebellum subiculum Region I of hippocampus proper prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phosphoprotein phosphatase activity protein dimerization activity protein serine/threonine phosphatase activity metal ion binding calmodulin binding protein binding protein heterodimerization activity enzyme binding calcium-dependent protein serine/threonine phosphatase activity hydrolase activity cyclosporin A binding calmodulin-dependent protein phosphatase activity Cellular component membrane plasma membrane calcineurin complex nucleoplasm Z discdkac mitochondrion sarcolemma nucleus cytosol cytoplasm cytoplasmic side of plasma membrane dendritic spine slit diaphragm cell projection synapse Schaffer collateral - CA1 synapse glutamatergic synapse Biological process multicellular organismal response to stress negative regulation of insulin secretion protein import into nucleus transition between fast and slow fiber negative regulation of chromatin binding response to amphetamine modulation of chemical synaptic transmission positive regulation of DNA-binding transcription factor activity response to calcium ion Fc-epsilon receptor signaling pathway cardiac muscle hypertrophy in response to stress negative regulation of dendrite morphogenesis skeletal muscle fiber development positive regulation of cardiac muscle hypertrophy in response to stress excitatory postsynaptic potential T cell activation cellular response to glucose stimulus calcium ion transport calcium-mediated signaling dephosphorylation positive regulation of transcription by RNA polymerase II Wnt signaling pathway, calcium modulating pathway positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of connective tissue replacement positive regulation of endocytosis G1/S transition of mitotic cell cycle protein dephosphorylation calcineurin-NFAT signaling cascade positive regulation of calcineurin-NFAT signaling cascade brain development positive regulation of cell migration skeletal muscle tissue regeneration positive regulation of cell adhesion calcineurin-mediated signaling postsynaptic modulation of chemical synaptic transmission ageing peptidyl-serine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5530 19055 Ensembl ENSG00000138814 ENSMUSG00000028161 UniProt Q08209 P63328 RefSeq (mRNA) NM_001130692 NM_000944 NM_001130691 NM_001293622 NM_008913 RefSeq (protein) NP_000935 NP_001124163 NP_001124164 NP_001280551 NP_032939 Location (UCSC) Chr 4: 101.02 – 101.35 Mb Chr 3: 136.38 – 136.64 Mb PubMed search [3] [4]
Wikidata
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