PPP3R1

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.^[5][6][7]

PPP3R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AUI, 1M63, 1MF8, 2P6B, 3LL8, 4F0Z, 4OR9, 4ORA, 4ORC, 4ORB
Identifiers
Aliases	PPP3R1, CALNB1, CNB, CNB1, protein phosphatase 3 regulatory subunit B, alpha
External IDs	OMIM: 601302; MGI: 107172; HomoloGene: 68099; GeneCards: PPP3R1; OMA:PPP3R1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p14 Start 68,178,857 bp[1] End 68,256,237 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A2 Start 17,109,263 bp[2] End 17,150,375 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 nucleus accumbens Achilles tendon right frontal lobe monocyte caudate nucleus prefrontal cortex putamen cerebellar hemisphere Amygdala Top expressed in CA3 field perirhinal cortex Region I of hippocampus proper olfactory tubercle entorhinal cortex dentate gyrus prefrontal cortex primary motor cortex primary visual cortex superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding protein domain specific binding metal ion binding calmodulin binding protein binding calcium-dependent protein serine/threonine phosphatase activity cyclosporin A binding phosphoprotein phosphatase activity phosphatase binding Cellular component cytoplasm cytosol membrane plasma membrane nucleoplasm sarcolemma calcineurin complex mitochondrion Biological process Fc-epsilon receptor signaling pathway positive regulation of transcription by RNA polymerase II protein dephosphorylation Wnt signaling pathway, calcium modulating pathway branching involved in blood vessel morphogenesis epithelial to mesenchymal transition heart development Schwann cell development myelination in peripheral nervous system calcineurin-NFAT signaling cascade protein localization to nucleus lung epithelial cell differentiation protein import into nucleus positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5534 19058 Ensembl ENSG00000221823 ENSMUSG00000033953 UniProt P63098 Q63810 RefSeq (mRNA) NM_000945 NM_024459 RefSeq (protein) NP_000936 NP_077779 Location (UCSC) Chr 2: 68.18 – 68.26 Mb Chr 11: 17.11 – 17.15 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.^[8]