PPT2

For the video game, see Puyo Puyo Tetris 2.

Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14, is an enzyme that in humans is encoded by the PPT2 gene.^[5][6][7]

PPT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PJA
Identifiers
Aliases	PPT2, C6orf8, G14, PPT-2, palmitoyl-protein thioesterase 2
External IDs	OMIM: 603298; MGI: 1860075; HomoloGene: 10448; GeneCards: PPT2; OMA:PPT2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,153,441 bp[1] End 32,163,678 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.19 cM Start 34,835,636 bp[2] End 34,847,484 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary right hemisphere of cerebellum tibial nerve left uterine tube canal of the cervix body of uterus skin of leg vagina ectocervix Top expressed in otic placode right kidney proximal tubule saccule ankle external carotid artery human kidney otic vesicle internal carotid artery molar More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity thiolester hydrolase activity palmitoyl-(protein) hydrolase activity palmitoyl hydrolase activity Cellular component lysosome lysosomal lumen extracellular exosome intracellular membrane-bounded organelle integral component of membrane membrane Biological process macromolecule depalmitoylation fatty-acyl-CoA biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9374 54397 Ensembl ENSG00000227600 ENSG00000231618 ENSG00000168452 ENSG00000228116 ENSG00000236649 ENSG00000206256 ENSG00000206329 ENSG00000221988 ENSMUSG00000015474 UniProt Q9UMR5 O35448 RefSeq (mRNA) NM_138934 NM_001204103 NM_005155 NM_138717 NM_019441 NM_001302393 NM_001302394 NM_001302395 NM_001302396 RefSeq (protein) NP_001191032 NP_005146 NP_619731 NP_001289322 NP_001289323 NP_001289324 NP_001289325 NP_062314 Location (UCSC) Chr 6: 32.15 – 32.16 Mb Chr 17: 34.84 – 34.85 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the palmitoyl protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins.^[5]