PRAM1

PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene.^[5][6][7]

PRAM1
Identifiers
Aliases	PRAM1, PML-RAR, PRAM-1, PML-RARA regulated adaptor molecule 1
External IDs	OMIM: 606466; MGI: 3576625; HomoloGene: 12963; GeneCards: PRAM1; OMA:PRAM1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 8,490,056 bp[1] End 8,502,640 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 33,857,030 bp[2] End 33,864,680 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood bone marrow cells trabecular bone spleen C1 segment upper lobe of left lung right lung appendix Top expressed in granulocyte bone marrow neural layer of retina cerebellar cortex morula primary oocyte embryo Hypothalamus spermatocyte blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding protein kinase binding Cellular component protein-containing complex plasma membrane Biological process signal transduction integrin-mediated signaling pathway regulation of neutrophil degranulation T cell receptor signaling pathway protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84106 378460 Ensembl ENSG00000133246 ENSMUSG00000032739 UniProt Q96QH2 Q6BCL1 RefSeq (mRNA) NM_032152 NM_001002842 RefSeq (protein) NP_115528 NP_001002842 Location (UCSC) Chr 19: 8.49 – 8.5 Mb Chr 17: 33.86 – 33.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), which is an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).^[7]

Interactions

PRAM1 has been shown to interact with TRIM27.^[8]