PRCP

This article is about the gene. For the postnominal, see Royal College of Physicians.

Lysosomal Pro-X carboxypeptidase is an enzyme that in humans is encoded by the PRCP gene.^[5][6]

PRCP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N2Z
Identifiers
Aliases	PRCP, HUMPCP, PCP, prolylcarboxypeptidase
External IDs	OMIM: 176785; MGI: 1919711; HomoloGene: 55867; GeneCards: PRCP; OMA:PRCP - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.1 Start 82,822,936 bp[1] End 82,970,584 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 92,523,678 bp[2] End 92,583,791 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii lymph node monocyte right adrenal cortex gallbladder periodontal fiber synovial joint left adrenal gland urethra left adrenal cortex Top expressed in genital tubercle tail of embryo membranous bone Rostral migratory stream Dermatocranium maxilla dermis right kidney body of femur mandible More reference expression data BioGPS More reference expression data
Gene ontology Molecular function serine-type carboxypeptidase activity peptidase activity protein binding carboxypeptidase activity serine-type peptidase activity hydrolase activity dipeptidyl-peptidase activity Cellular component basal part of cell plasma membrane lysosome extracellular exosome azurophil granule membrane ficolin-1-rich granule membrane Biological process blood coagulation, intrinsic pathway glucose homeostasis regulation of reactive oxygen species metabolic process energy homeostasis plasma kallikrein-kinin cascade regulation of thyroid hormone mediated signaling pathway neutrophil degranulation negative regulation of systemic arterial blood pressure proteolysis regulation of blood vessel endothelial cell migration angiogenesis involved in wound healing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5547 72461 Ensembl ENSG00000137509 ENSMUSG00000061119 UniProt P42785 Q7TMR0 RefSeq (mRNA) NM_005040 NM_199418 NM_001319214 NM_028243 RefSeq (protein) NP_001306143 NP_005031 NP_955450 NP_082519 Location (UCSC) Chr 11: 82.82 – 82.97 Mb Chr 7: 92.52 – 92.58 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotensin II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[6]