PRDM2

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.^[5][6]

PRDM2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2JV0, 2QPW
Identifiers
Aliases	PRDM2, HUMHOXY1, KMT8, MTB-ZF, RIZ, RIZ1, RIZ2, PR domain 2, PR/SET domain 2, KMT8A
External IDs	OMIM: 601196; MGI: 107628; HomoloGene: 40822; GeneCards: PRDM2; OMA:PRDM2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.21 Start 13,700,188 bp[1] End 13,825,079 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E1|4 76.84 cM Start 143,107,391 bp[2] End 143,212,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve secondary oocyte buccal mucosa cell middle temporal gyrus epithelium of colon Brodmann area 46 Brodmann area 10 frontal pole bone marrow cells Brodmann area 23 Top expressed in interventricular septum spermatocyte spermatid granulocyte zygote tail of embryo genital tubercle otic vesicle muscle of thigh visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity methyltransferase activity transferase activity DNA binding zinc ion binding histone-lysine N-methyltransferase activity metal ion binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific chromatin DNA binding sequence-specific DNA binding Cellular component nucleus Golgi apparatus Biological process histone lysine methylation methylation regulation of transcription, DNA-templated determination of adult lifespan transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7799 110593 Ensembl ENSG00000116731 ENSMUSG00000057637 UniProt Q13029 n/a RefSeq (mRNA) NM_001007257 NM_001135610 NM_012231 NM_015866 NM_001393986 NM_001393987 NM_001393988 NM_001081355 NM_001256380 RefSeq (protein) NP_001007258 NP_001129082 NP_036363 NP_056950 n/a Location (UCSC) Chr 1: 13.7 – 13.83 Mb Chr 4: 143.11 – 143.21 Mb PubMed search [3] [4]
Wikidata
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Function

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.^[6]

Interactions

PRDM2 has been shown to interact with Estrogen receptor alpha^[7] and Retinoblastoma protein.^[5]