PRDX4

Peroxiredoxin-4 is a protein that in humans is encoded by the PRDX4 gene.^[5][6] It is a member of the peroxiredoxin family of antioxidant enzymes.

PRDX4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PN8, 3TJB, 3TJF, 3TJG, 3TJJ, 3TJK, 3TKP, 3TKQ, 3TKR, 3TKS, 4RQX
Identifiers
Aliases	PRDX4, AOE37-2, AOE372, HEL-S-97n, PRX-4, peroxiredoxin 4
External IDs	OMIM: 300927; MGI: 1859815; HomoloGene: 4672; GeneCards: PRDX4; OMA:PRDX4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.11 Start 23,664,262 bp[1] End 23,686,397 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F3|X 72.38 cM Start 154,106,914 bp[2] End 154,123,750 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas tibia islet of Langerhans parotid gland stromal cell of endometrium beta cell gonad right testis left testis cartilage tissue Top expressed in saccule otic placode otic vesicle external carotid artery dermis endocardial cushion maxillary prominence Gonadal ridge vas deferens cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity peroxidase activity thioredoxin peroxidase activity antioxidant activity protein binding peroxiredoxin activity oxidoreductase activity Cellular component cytoplasm cytosol smooth endoplasmic reticulum endoplasmic reticulum mitochondrion extracellular exosome nucleus extracellular space secretory granule lumen ficolin-1-rich granule lumen extracellular region Biological process male gonad development 4-hydroxyproline metabolic process extracellular matrix organization I-kappaB phosphorylation protein maturation by protein folding cell redox homeostasis reactive oxygen species metabolic process spermatogenesis negative regulation of male germ cell proliferation cellular oxidant detoxification neutrophil degranulation response to oxidative stress hydrogen peroxide catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10549 53381 Ensembl ENSG00000123131 ENSMUSG00000025289 UniProt Q13162 O08807 RefSeq (mRNA) NM_006406 NM_016764 NM_001313711 RefSeq (protein) NP_006397 NP_001300640 NP_058044 Location (UCSC) Chr X: 23.66 – 23.69 Mb Chr X: 154.11 – 154.12 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is an antioxidant enzyme of the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.^[6]

Interactions

PRDX4 has been shown to interact with Peroxiredoxin 1.^[5]