PRDX6

Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene.^[5][6] It is a member of the peroxiredoxin family of antioxidant enzymes. Peroxiredoxin 6 is widely distributed in several organs, especially the lungs.^[7]

PRDX6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PRX, 5B6N, 5B6M
Identifiers
Aliases	PRDX6, 1-Cys, AOP2, HEL-S-128m, NSGPx, PRX, aiPLA2, p29, peroxiredoxin 6, LPCAT-5
External IDs	OMIM: 602316; MGI: 894320; HomoloGene: 3606; GeneCards: PRDX6; OMA:PRDX6 - orthologs
EC number	1.11.1.9
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.1 Start 173,477,330 bp[1] End 173,488,815 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.1|1 69.75 cM Start 161,067,682 bp[2] End 161,078,789 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis gastrocnemius muscle gastric mucosa amniotic fluid abdominal fat right auricle of heart peritoneum mucosa of transverse colon germinal epithelium rectum Top expressed in left colon olfactory epithelium right lung right lung lobe corneal stroma gastrula seminal vesicula superior surface of tongue epiblast left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peroxidase activity catalytic activity protein binding peroxiredoxin activity oxidoreductase activity hydrolase activity ubiquitin protein ligase binding antioxidant activity cadherin binding glutathione peroxidase activity protein homodimerization activity calcium-independent phospholipase A2 activity phospholipase A2 activity Cellular component cytoplasm cytosol membrane lysosome extracellular exosome extracellular region extracellular space azurophil granule lumen nucleus perinuclear region of cytoplasm Biological process lipid metabolism lipid catabolic process hydrogen peroxide catabolic process metabolism cell redox homeostasis neutrophil degranulation response to oxidative stress cellular response to oxidative stress glycerophospholipid catabolic process cellular oxidant detoxification positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9588 11758 Ensembl ENSG00000117592 ENSMUSG00000026701 UniProt P30041 O08709 RefSeq (mRNA) NM_004905 NM_001303408 NM_007453 RefSeq (protein) NP_004896 NP_001290337 NP_031479 Location (UCSC) Chr 1: 173.48 – 173.49 Mb Chr 1: 161.07 – 161.08 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.^[6]