PREB

Prolactin regulatory element-binding protein is a protein that in humans is encoded by the PREB gene.^[5][6][7]

PREB
Identifiers
Aliases	PREB, SEC12, prolactin regulatory element binding
External IDs	OMIM: 606395; MGI: 1355326; HomoloGene: 40877; GeneCards: PREB; OMA:PREB - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,130,756 bp[1] End 27,134,666 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 30,950,853 bp[2] End 30,960,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gastrocnemius muscle left uterine tube muscle of thigh body of pancreas apex of heart body of uterus right ovary granulocyte mucosa of transverse colon Top expressed in fossa condyle Paneth cell granulocyte motor neuron seminal vesicula yolk sac internal carotid artery neural layer of retina endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding guanyl-nucleotide exchange factor activity protein binding GTPase activator activity GTPase binding Cellular component integral component of membrane endoplasmic reticulum membrane membrane endoplasmic reticulum endoplasmic reticulum exit site Golgi membrane nucleus integral component of endoplasmic reticulum membrane Biological process protein transport IRE1-mediated unfolded protein response vesicle-mediated transport transcription, DNA-templated positive regulation of GTPase activity regulation of transcription, DNA-templated COPII vesicle coating protein exit from endoplasmic reticulum endoplasmic reticulum to Golgi vesicle-mediated transport regulation of COPII vesicle coating protein secretion transport regulation of molecular function regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10113 50907 Ensembl ENSG00000138073 ENSMUSG00000045302 UniProt Q9HCU5 Q9WUQ2 RefSeq (mRNA) NM_001330484 NM_001330485 NM_001330486 NM_001330487 NM_013388 NM_001294302 NM_016703 RefSeq (protein) NP_001317413 NP_001317414 NP_001317415 NP_001317416 NP_037520 NP_001281231 NP_057912 Location (UCSC) Chr 2: 27.13 – 27.13 Mb Chr 5: 30.95 – 30.96 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.^[7]