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PRIMA1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

PRIMA1
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Proline-rich membrane anchor 1, also known as PRiMA, is a protein that in humans is encoded by the PRIMA1 gene.[4][5]

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Function

PRiMA functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.[4] This is accomplished by the proline rich anchor domain (PRAD) of PRIMA1 which anchors the tetramer of AChE into the plasma membrane of neural cells and myocytes.[6] The PRAD interacts with the C-terminal T-peptide of AChE.[7]

PRiMA plays a role in targeting AChE to the cell surface and, in neuroblastoma cells, PRiMA the limiting factor of such targeting.[5] In both mice and humans, PRiMA exists as two alternative splice variants that differ in their cytoplasmic regions.

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Clinical significance

The severity of neurogenerative diseases, such as Alzheimer’s, can be related to the degradation of AChE.[8]

References

Further reading

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