PRKAA2

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.^[5][6]

PRKAA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H6D, 2LTU, 2YZA, 3AQV, 4CFE, 4CFF, 4ZHX, 5EZV
Identifiers
Aliases	PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA, protein kinase AMP-activated catalytic subunit alpha 2
External IDs	OMIM: 600497; MGI: 1336173; HomoloGene: 4551; GeneCards: PRKAA2; OMA:PRKAA2 - orthologs
EC number	2.7.11.27
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.2 Start 56,645,314 bp[1] End 56,715,335 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C6 Start 104,887,071 bp[2] End 104,967,087 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii right ventricle body of tongue renal medulla saphenous vein muscle of thigh vena cava Brodmann area 23 Top expressed in triceps brachii muscle medial head of gastrocnemius muscle vastus lateralis muscle sternocleidomastoid muscle tibialis anterior muscle knee joint digastric muscle temporal muscle soleus muscle extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity [acetyl-CoA carboxylase kinase activity] AMP-activated protein kinase activity histone serine kinase activity chromatin binding metal ion binding kinase activity protein serine/threonine kinase activity protein binding [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity] protein serine/threonine/tyrosine kinase activity ATP binding Cellular component cytoplasm cytosol nucleoplasm nucleotide-activated protein kinase complex nucleus Golgi apparatus nuclear speck cytoplasmic stress granule axon dendrite soma Biological process carnitine shuttle steroid metabolic process intracellular signal transduction cellular response to glucose starvation sterol biosynthetic process lipid biosynthetic process regulation of transcription, DNA-templated glucose homeostasis positive regulation of autophagy phosphorylation rhythmic process lipid metabolism response to stress negative regulation of apoptotic process cholesterol metabolic process Wnt signaling pathway regulation of fatty acid biosynthetic process fatty acid metabolic process transcription, DNA-templated cellular response to prostaglandin E stimulus autophagy protein phosphorylation negative regulation of TOR signaling positive regulation of macroautophagy fatty acid biosynthetic process fatty acid homeostasis regulation of circadian rhythm cellular response to nutrient levels regulation of gene expression cholesterol biosynthetic process response to muscle activity positive regulation of glycolytic process macroautophagy signal transduction steroid biosynthetic process regulation of signal transduction by p53 class mediator regulation of macroautophagy chromatin organization negative regulation of gene expression cellular response to oxidative stress regulation of stress granule assembly regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus energy homeostasis positive regulation of protein localization negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5563 108079 Ensembl ENSG00000162409 ENSMUSG00000028518 UniProt P54646 Q8BRK8 RefSeq (mRNA) NM_006252 NM_178143 NM_001356568 RefSeq (protein) NP_006243 NP_835279 NP_001343497 Location (UCSC) Chr 1: 56.65 – 56.72 Mb Chr 4: 104.89 – 104.97 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.^[6]