PRKAG1

5'-AMP-activated protein kinase subunit gamma-1 is an enzyme that in humans is encoded by the PRKAG1 gene.^[5][6][7]

PRKAG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UV4, 2UV5, 2UV6, 2UV7, 4CFE, 4CFF, 4RER, 4REW, 5EZV, 4ZHX
Identifiers
Aliases	PRKAG1, AMPKG, protein kinase AMP-activated non-catalytic subunit gamma 1
External IDs	OMIM: 602742; MGI: 108411; HomoloGene: 99712; GeneCards: PRKAG1; OMA:PRKAG1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 49,002,274 bp[1] End 49,018,807 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 54.73 cM Start 98,710,678 bp[2] End 98,729,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle islet of Langerhans right adrenal cortex left ventricle left adrenal gland triceps brachii muscle left adrenal cortex muscle of thigh right auricle of heart apex of heart Top expressed in saccule granulocyte otic placode otic vesicle right ventricle fetal liver hematopoietic progenitor cell molar internal carotid artery external carotid artery gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity cAMP-dependent protein kinase activity ADP binding AMP-activated protein kinase activity AMP binding protein binding cAMP-dependent protein kinase regulator activity protein kinase binding ATP binding adenyl ribonucleotide binding Cellular component cytosol membrane nucleotide-activated protein kinase complex extracellular exosome nucleus nucleoplasm Biological process lipid metabolism fatty acid metabolic process regulation of glycolytic process protein phosphorylation positive regulation of gene expression fatty acid biosynthetic process spermatogenesis macroautophagy signal transduction positive regulation of protein kinase activity regulation of signal transduction by p53 class mediator regulation of macroautophagy import into nucleus regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5571 19082 Ensembl ENSG00000181929 ENSMUSG00000067713 UniProt P54619 O54950 RefSeq (mRNA) NM_001206709 NM_001206710 NM_002733 NM_212461 NM_016781 RefSeq (protein) NP_001193638 NP_001193639 NP_002724 NP_058061 Location (UCSC) Chr 12: 49 – 49.02 Mb Chr 15: 98.71 – 98.73 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.^[7]

Interactions

PRKAG1 has been shown to interact with PRKAB2^[8] and PRKAB1.^[8]