Protein kinase D1

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.^[5][6][7]

PRKD1
Identifiers
Aliases	PRKD1, PKC-MU, PKCM, PKD, PRKCM, Protein kinase D1, CHDED
External IDs	OMIM: 605435; MGI: 99879; HomoloGene: 55680; GeneCards: PRKD1; OMA:PRKD1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 29,576,479 bp[1] End 30,191,898 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 B3 Start 50,341,231 bp[2] End 50,649,098 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone seminal vesicula thoracic aorta ascending aorta testicle saphenous vein Descending thoracic aorta right coronary artery popliteal artery tibial arteries Top expressed in primitive streak substantia nigra external carotid artery internal carotid artery fossa primary oocyte condyle renal corpuscle epithelium of lens vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein kinase C activity metal ion binding kinase activity protein binding identical protein binding ATP binding protein serine/threonine kinase activity Cellular component Golgi apparatus membrane plasma membrane integral component of plasma membrane autophagosome membrane cytoplasm trans-Golgi network cytosol Biological process negative regulation of endocytosis cell differentiation intracellular signal transduction positive regulation of endothelial cell proliferation regulation of protein stability Golgi organization phosphorylation immune system process positive regulation of endothelial cell chemotaxis protein kinase D signaling sphingolipid biosynthetic process negative regulation of cell death nervous system development positive regulation of peptidyl-serine phosphorylation positive regulation of angiogenesis positive regulation of endothelial cell migration protein phosphorylation positive regulation of histone deacetylase activity positive regulation of CREB transcription factor activity vascular endothelial growth factor receptor signaling pathway regulation of integrin-mediated signaling pathway positive regulation of NF-kappaB transcription factor activity angiogenesis positive regulation of blood vessel endothelial cell migration positive regulation of neuron projection development positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling integrin-mediated signaling pathway protein autophosphorylation cellular response to oxidative stress cellular response to vascular endothelial growth factor stimulus Ras protein signal transduction cell population proliferation inflammatory response innate immune response signal transduction positive regulation of transcription by RNA polymerase II apoptotic process positive regulation of autophagy cellular response to amino acid starvation positive regulation of phosphatidylinositol 3-kinase activity cellular response to hydroperoxide regulation of keratinocyte proliferation positive regulation of osteoblast differentiation Golgi vesicle transport peptidyl-serine phosphorylation peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5587 18760 Ensembl ENSG00000184304 ENSMUSG00000002688 UniProt Q15139 Q62101 RefSeq (mRNA) NM_002742 NM_001330069 NM_001348390 NM_008858 RefSeq (protein) NP_001316998 NP_002733 NP_001335319 NP_032884 NP_001369743 NP_001369744 NP_001369745 Location (UCSC) Chr 14: 29.58 – 30.19 Mb Chr 12: 50.34 – 50.65 Mb PubMed search [3] [4]
Wikidata
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Function

Members of the protein kinase D (PKD) family function in many extracellular receptor-mediated signal transduction pathways. The PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.[supplied by OMIM]^[7]

Interactions

Protein kinase D1 has been shown to interact with:

• Bruton's tyrosine kinase,^[8]
• C1QBP,^[9]
• Centaurin, alpha 1,^[10]
• Metallothionein 2A,^[11] and
• YWHAQ.^[9][12]