YWHAQ

14-3-3 protein theta is a protein that in humans is encoded by the YWHAQ gene.^[4]

YWHAQ
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2BTP, 5IQP
Identifiers
Aliases	YWHAQ, 14-3-3, 1C5, HS1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
External IDs	OMIM: 609009; MGI: 3650241; HomoloGene: 105677; GeneCards: YWHAQ; OMA:YWHAQ - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 9,583,967 bp[1] End 9,630,997 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell Pons superior vestibular nucleus parotid gland inferior ganglion of vagus nerve secondary oocyte Epithelium of choroid plexus hair follicle human penis n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter binding protein domain specific binding protein N-terminus binding 14-3-3 protein binding protein C-terminus binding protein binding identical protein binding Cellular component cytoplasm cytosol membrane focal adhesion extracellular exosome cytoplasmic vesicle membrane mitochondrion protein-containing complex synapse Biological process protein targeting substantia nigra development negative regulation of ion transmembrane transport positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway membrane organization negative regulation of transcription, DNA-templated small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10971 102634437 Ensembl ENSG00000134308 n/a UniProt P27348 n/a RefSeq (mRNA) NM_006826 n/a RefSeq (protein) NP_006817 n/a Location (UCSC) Chr 2: 9.58 – 9.63 Mb n/a PubMed search [2] [3]
Wikidata
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Function

This gene product belongs to the 14-3-3 family of proteins that mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence that is polymorphic; however, there is no correlation between the repeat number and the disease.^[5]

Interactions

YWHAQ has been shown to interact with:

• BAX,^[6]
• BAD,^[7][8]
• C-Raf,^{[9][10][11][12]}
• CRTC2,^[13][9]
• CBL^[12][14]
• HDAC5,^[15]
• MEF2D,^[16]
• NRIP1,^[17]
• PFKFB2,^[18]
• PRKD1,^[19][20]
• PRKCZ,^[11]
• TERT,^[21] and
• UCP3.^[22]