PRM2

Protamine 2 is a protein that in humans is encoded by the PRM2 gene.^[5]

PRM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AWR
Identifiers
Aliases	PRM2, CT94.2, protamine 2
External IDs	OMIM: 182890; MGI: 97766; GeneCards: PRM2; OMA:PRM2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.13 Start 11,275,639 bp[1] End 11,276,480 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 5.84 cM Start 10,609,244 bp[2] End 10,613,998 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis male germ cell left testis sperm testicle caput epididymis right coronary artery tail of epididymis ectocervix right uterine tube Top expressed in seminiferous tubule spermatid spermatocyte morula zygote blastocyst primary oocyte secondary oocyte muscle tissue striated muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding zinc ion binding cadmium ion binding Cellular component nucleosome nucleus nucleoplasm chromosome Biological process multicellular organism development cell differentiation chromosome condensation nucleus organization spermatid development spermatogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5620 19119 Ensembl ENSG00000122304 ENSMUSG00000038015 UniProt P04554 P07978 RefSeq (mRNA) NM_001286356 NM_001286357 NM_001286358 NM_001286359 NM_002762 NM_008933 RefSeq (protein) NP_001273285 NP_001273286 NP_001273287 NP_001273288 NP_002753 NP_032959 Location (UCSC) Chr 16: 11.28 – 11.28 Mb Chr 16: 10.61 – 10.61 Mb PubMed search [3] [4]
Wikidata
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Function

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, and are the major DNA-binding proteins in the nucleus of sperm in many vertebrates. They package the sperm DNA into a highly condensed complex in a volume less than 5% of a somatic cell nucleus.

Many mammalian species have only one protamine (protamine 1); however, a few species, including human and mouse, have two. This gene encodes protamine 2, which is cleaved to give rise to a family of protamine 2 peptides. Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Sep 2015].