PRMT6

Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene.^[5][6]

PRMT6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HC4, 4QPP, 4QQK, 4Y2H, 4Y30, 5EGS, 5E8R, 5HZM
Identifiers
Aliases	PRMT6, HRMT1L6, protein arginine methyltransferase 6
External IDs	OMIM: 608274; MGI: 2139971; HomoloGene: 10024; GeneCards: PRMT6; OMA:PRMT6 - orthologs
EC number	2.1.1.321
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 107,056,674 bp[1] End 107,067,636 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 110,153,425 bp[2] End 110,158,314 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad islet of Langerhans palpebral conjunctiva right adrenal cortex mucosa of sigmoid colon metanephros testicle left adrenal gland left adrenal cortex prefrontal cortex Top expressed in renal corpuscle medullary collecting duct spermatocyte endocardial cushion epiblast embryo primitive streak yolk sac tail of embryo right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function methyltransferase activity transferase activity histone methyltransferase activity protein-arginine omega-N monomethyltransferase activity histone methyltransferase activity (H4-R3 specific) histone binding protein-arginine omega-N asymmetric methyltransferase activity chromatin binding histone methyltransferase activity (H2A-R3 specific) histone methyltransferase activity (H3-R2 specific) protein binding protein-arginine N-methyltransferase activity histone-arginine N-methyltransferase activity Cellular component nucleoplasm nucleus nucleolus cytosol Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated cellular response to DNA damage stimulus cellular senescence methylation peptidyl-arginine methylation, to asymmetrical-dimethyl arginine histone methylation viral process negative regulation of transcription, DNA-templated DNA repair base-excision repair protein methylation histone H4-R3 methylation regulation of megakaryocyte differentiation chromatin organization histone H3-R2 methylation peptidyl-arginine N-methylation negative regulation of histone H3-K4 methylation regulation of signal transduction by p53 class mediator histone arginine methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55170 99890 Ensembl ENSG00000198890 ENSMUSG00000049300 UniProt Q96LA8 Q6NZB1 RefSeq (mRNA) NM_018137 NM_178891 RefSeq (protein) NP_060607 NP_849222 Location (UCSC) Chr 1: 107.06 – 107.07 Mb Chr 3: 110.15 – 110.16 Mb PubMed search [3] [4]
Wikidata
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Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM]^[6]