PRND

This article is about Prion Protein 2 (dublet). For "Parking Reverse Neutral Drive", see Automatic transmission.

Prion protein 2 (dublet), also known as PRND, or Doppel protein, is a protein which in humans is encoded by the PRND gene.^[5]

PRND
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LG4
Identifiers
Aliases	PRND, DOPPEL, DPL, PrPLP, dJ1068H6.4, prion protein 2 (dublet), prion like protein doppel
External IDs	OMIM: 604263; MGI: 1346999; HomoloGene: 8236; GeneCards: PRND; OMA:PRND - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 4,721,909 bp[1] End 4,728,460 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F2|2 64.07 cM Start 131,792,781 bp[2] End 131,798,050 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis Epithelium of choroid plexus visceral pleura testicle skin of hip parietal pleura body of uterus gallbladder myometrium Top expressed in testicle spermatocyte stomach ventricle of the heart neural tube genital tubercle midgut spermatid Hindgut embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function copper ion binding metal ion binding Cellular component anchored component of membrane membrane extracellular region plasma membrane anchored component of external side of plasma membrane Biological process protein homooligomerization cellular copper ion homeostasis acrosome reaction single fertilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23627 26434 Ensembl ENSG00000171864 ENSMUSG00000027338 UniProt Q9UKY0 Q9QUG3 RefSeq (mRNA) NM_012409 NM_001126338 NM_001278257 NM_001278520 NM_023043 RefSeq (protein) NP_036541 NP_001119810 NP_001265186 NP_001265449 NP_075530 Location (UCSC) Chr 20: 4.72 – 4.73 Mb Chr 2: 131.79 – 131.8 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders.^[5]