PRPF3

U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.^[5]

PRPF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4Q, 3JCR
Identifiers
Aliases	PRPF3, pre-mRNA processing factor 3, HPRP3, HPRP3P, PRP3, Prp3p, RP18, SNRNP90
External IDs	OMIM: 607301; MGI: 1918017; HomoloGene: 3447; GeneCards: PRPF3; OMA:PRPF3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 150,321,479 bp[1] End 150,353,233 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,737,436 bp[2] End 95,763,197 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube left ovary right ovary left lobe of thyroid gland right lobe of thyroid gland anterior pituitary cerebellar hemisphere right hemisphere of cerebellum body of uterus Top expressed in tail of embryo genital tubercle primitive streak ventricular zone epiblast neural layer of retina otic vesicle yolk sac otic placode primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding RNA binding Cellular component Cajal body U4/U6 x U5 tri-snRNP complex spliceosomal complex nucleus nucleoplasm cytosol nuclear speck protein-containing complex U2-type precatalytic spliceosome Biological process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome mRNA processing spliceosomal tri-snRNP complex assembly RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9129 70767 Ensembl ENSG00000117360 ENSMUSG00000015748 UniProt O43395 Q922U1 RefSeq (mRNA) NM_004698 NM_001350529 NM_027541 NM_001316751 RefSeq (protein) NP_004689 NP_001337458 NP_001303680 NP_081817 Location (UCSC) Chr 1: 150.32 – 150.35 Mb Chr 3: 95.74 – 95.76 Mb PubMed search [3] [4]
Wikidata
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Function

See also: U4 spliceosomal RNA and U6 spliceosomal RNA

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF3 is one of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]^[5]

Interactions

PRPF3 has been shown to interact with DVL3.^[6]