PRPF4B

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.^[5][6][7]

PRPF4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IAN, 4IFC, 4IIR, 4IJP
Identifiers
Aliases	PRPF4B, PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1, pre-mRNA processing factor 4B
External IDs	OMIM: 602338; MGI: 109584; HomoloGene: 134085; GeneCards: PRPF4B; OMA:PRPF4B - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.2 Start 4,021,267 bp[1] End 4,064,983 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.3 Start 34,875,302 bp[2] End 34,906,064 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Epithelium of choroid plexus mucosa of paranasal sinus Achilles tendon epithelium of nasopharynx ventricular zone left ovary body of uterus right ovary right uterine tube Top expressed in fossa condyle genital tubercle Paneth cell tail of embryo lobe of cerebellum cerebellar vermis substantia nigra otic placode saccule More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity protein kinase activity protein serine/threonine kinase activity nucleotide binding protein binding ATP binding cyclin-dependent protein serine/threonine kinase activity RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex nucleus chromosome nuclear speck Biological process mRNA splicing, via spliceosome protein phosphorylation mRNA processing RNA splicing phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8899 19134 Ensembl ENSG00000112739 ENSMUSG00000021413 UniProt Q13523 Q61136 RefSeq (mRNA) NM_003913 NM_176800 NM_013830 RefSeq (protein) NP_003904 NP_038858 Location (UCSC) Chr 6: 4.02 – 4.06 Mb Chr 13: 34.88 – 34.91 Mb PubMed search [3] [4]
Wikidata
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Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).^[7]

Interactions

PRPF4B has been shown to interact with Pinin.^[8]