PRPF6

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.^[5][6][7]

PRPF6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	PRPF6, ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6, pre-mRNA processing factor 6
External IDs	OMIM: 613979; MGI: 1922946; HomoloGene: 5368; GeneCards: PRPF6; OMA:PRPF6 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,981,132 bp[1] End 64,033,100 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 181,233,661 bp[2] End 181,297,453 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii paraflocculus of cerebellum beta cell right hemisphere of cerebellum ganglionic eminence right uterine tube ventricular zone skin of leg Achilles tendon popliteal artery Top expressed in supraoptic nucleus aortic valve ascending aorta Rostral migratory stream fossa condyle internal carotid artery external carotid artery zygote primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity protein binding androgen receptor binding RNA binding ribonucleoprotein complex binding Cellular component U4/U6 x U5 tri-snRNP complex catalytic step 2 spliceosome membrane U5 snRNP spliceosomal complex nucleus nucleoplasm nuclear speck U2-type precatalytic spliceosome Biological process mRNA splicing, via spliceosome RNA processing spliceosomal tri-snRNP complex assembly RNA splicing, via transesterification reactions mRNA processing spliceosomal complex assembly RNA localization positive regulation of transcription by RNA polymerase II RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 24148 68879 Ensembl ENSG00000101161 ENSMUSG00000002455 UniProt O94906 Q91YR7 RefSeq (mRNA) NM_012469 NM_133701 RefSeq (protein) NP_036601 NP_598462 Location (UCSC) Chr 20: 63.98 – 64.03 Mb Chr 2: 181.23 – 181.3 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.^[7]

Interactions

PRPF6 has been shown to interact with TXNL4B,^[8] ARAF^[9][10] and Androgen receptor.^[11]