PRRX2

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.^[5][6]

PRRX2
Identifiers
Aliases	PRRX2, PMX2, PRX2, paired related homeobox 2
External IDs	OMIM: 604675; MGI: 98218; HomoloGene: 7524; GeneCards: PRRX2; OMA:PRRX2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 129,665,647 bp[1] End 129,722,674 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 21.74 cM Start 30,724,984 bp[2] End 30,771,263 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ascending aorta periodontal fiber Descending thoracic aorta gingival epithelium tibial arteries vena cava gonad skin of leg canal of the cervix cartilage tissue Top expressed in hand calvaria maxillary prominence mandibular prominence external carotid artery nasal septum upper jaw dermis foot abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51450 20204 Ensembl ENSG00000167157 ENSMUSG00000039476 UniProt Q99811 Q06348 RefSeq (mRNA) NM_016307 NM_009116 RefSeq (protein) NP_057391 NP_033142 Location (UCSC) Chr 9: 129.67 – 129.72 Mb Chr 2: 30.72 – 30.77 Mb PubMed search [3] [4]
Wikidata
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Function

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.^[6]