PRSS3

Protease, serine, 3 is a protein that in humans is encoded by the PRSS3 gene.^[5]

PRSS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H4W, 2R9P, 3L33, 3L3T, 3P92, 3P95, 4DG4, 4U30, 4U32, 5C67
Identifiers
Aliases	PRSS3, MTG, PRSS4, T9, TRY3, TRY4, protease, serine 3, serine protease 3
External IDs	OMIM: 613578; MGI: 102757; HomoloGene: 106639; GeneCards: PRSS3; OMA:PRSS3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 33,750,679 bp[1] End 33,799,231 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 41,279,203 bp[2] End 41,282,466 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas mucosa of ileum mucosa of transverse colon jejunal mucosa duodenum mucosa of sigmoid colon islet of Langerhans rectum beta cell gums Top expressed in pancreas islet of Langerhans stomach embryo colon quadriceps femoris muscle duodenum esophagus jejunum primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding peptidase activity serine-type endopeptidase activity protein binding hydrolase activity metal ion binding serine-type peptidase activity Cellular component extracellular region extracellular space tertiary granule lumen Biological process digestion cobalamin metabolic process zymogen activation endothelial cell migration proteolysis antimicrobial humoral response neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5646 22074 Ensembl ENSG00000010438 ENSMUSG00000054106 UniProt P35030 Q9R0T7 RefSeq (mRNA) NM_001197097 NM_001197098 NM_002771 NM_007343 NM_011646 RefSeq (protein) NP_001184026 NP_001184027 NP_002762 NP_031369 NP_035776 Location (UCSC) Chr 9: 33.75 – 33.8 Mb Chr 6: 41.28 – 41.28 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.