PRSS8

Prostasin is a protein that in humans is encoded by the PRSS8 gene.^[5][6][7]

PRSS8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DFJ, 3DFL, 3E0N, 3E0P, 3E16, 3E1X, 3FVF, 3GYL, 3GYM
Identifiers
Aliases	PRSS8, CAP1, PROSTASIN, protease, serine 8, serine protease 8
External IDs	OMIM: 600823; MGI: 1923810; HomoloGene: 20613; GeneCards: PRSS8; OMA:PRSS8 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 31,131,433 bp[1] End 31,135,727 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.84 cM Start 127,524,888 bp[2] End 127,529,276 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon minor salivary glands mucosa of ileum body of pancreas skin of abdomen skin of leg olfactory zone of nasal mucosa corpus epididymis rectum duodenum Top expressed in right kidney proximal tubule trophoblast cell yolk sac human kidney saccule inner renal medulla vestibular membrane of cochlear duct lacrimal gland otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity protein binding hydrolase activity sodium channel regulator activity endopeptidase activity Cellular component integral component of membrane extracellular region plasma membrane extracellular exosome membrane extrinsic component of plasma membrane anchored component of plasma membrane extracellular space Biological process proteolysis positive regulation of sodium ion transport cornification regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5652 76560 Ensembl ENSG00000052344 ENSMUSG00000030800 UniProt Q16651 Q9ESD1 RefSeq (mRNA) NM_002773 NM_133351 RefSeq (protein) NP_002764 n/a Location (UCSC) Chr 16: 31.13 – 31.14 Mb Chr 7: 127.52 – 127.53 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

The protein is implicated in epithelial sodium channel regulation^[8] and may help regulate a variety of tissue functions that involve a sodium channel.^[9]

High prostasin plasma levels may be associated with a higher risk for diabetes and death from cancer, especially in people with high blood sugar.^{[10][unreliable medical source]}