PSG2

Function

Human pregnancy-specific glycoproteins (PSGs) are a family of proteins synthesized in large quantities by the placental trophoblast and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has shown that PSG forms a subset of the carcinoembryonic antigen (CEA) gene family that belongs to the immunoglobulin superfamily genes. Members of the CEA family consist of a single N domain structurally similar to the immunoglobulin variable domain, followed by a variable number of constant immunoglobulin-like A and/or B domains. Most PSGs have the Argglyasp (RGD) motif in the N-terminal domain. It has been shown to act as an adhesion recognition signal for some integrins.^[1]

PSG2
Identifiers
Aliases	PSG2, CEA, PSBG2, PSG1, pregnancy specific beta-1-glycoprotein 2
External IDs	OMIM: 176391; GeneCards: PSG2; OMA:PSG2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[2] Band 19q13.31 Start 43,064,209 bp[2] End 43,083,045 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta decidua testicle gonad stromal cell of endometrium muscle of thigh monocyte sural nerve renal cortex primary visual cortex n/a More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component extracellular region cellular component Biological process cell migration female pregnancy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5670 n/a Ensembl ENSG00000242221 n/a UniProt P11465 n/a RefSeq (mRNA) NM_031246 n/a RefSeq (protein) NP_112536 n/a Location (UCSC) Chr 19: 43.06 – 43.08 Mb n/a PubMed search [3] n/a
Wikidata
View/Edit Human

Pregnancy-specific beta-1-glycoprotein 2 is a protein that in humans is encoded by the PSG2 gene.^[4][5]