PSKH1

Protein Serine/threonine-protein kinase H1 is a Ser/Thr protein kinase that is encoded by the PSKH1 gene in humans and is associated with organelle membranes. PSKH1 resides within, and transits between, organelles in the human secretory pathway notably the Endoplasmic Reticulum.^[5][6]

PSKH1
Identifiers
Aliases	PSKH1, protein serine kinase H1
External IDs	OMIM: 177015; MGI: 3528383; HomoloGene: 48461; GeneCards: PSKH1; OMA:PSKH1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,893,254 bp[1] End 67,929,676 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 106,627,073 bp[2] End 106,658,410 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium mucosa of transverse colon apex of heart body of stomach body of pancreas right coronary artery popliteal artery tibial arteries left ovary left adrenal cortex Top expressed in hand genital tubercle zygote internal carotid artery tail of embryo external carotid artery secondary oocyte foot maxillary prominence mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding ATP binding protein serine/threonine kinase activity Cellular component cytoplasm Golgi apparatus nuclear speck endoplasmic reticulum membrane membrane plasma membrane microtubule organizing center endoplasmic reticulum cytoskeleton nucleus intracellular anatomical structure nucleoplasm cellular component Biological process phosphorylation protein phosphorylation heart development determination of left/right symmetry peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5681 244631 Ensembl ENSG00000159792 ENSMUSG00000048310 UniProt P11801 Q91YA2 RefSeq (mRNA) NM_006742 NM_173432 RefSeq (protein) NP_006733 NP_775608 Location (UCSC) Chr 16: 67.89 – 67.93 Mb Chr 8: 106.63 – 106.66 Mb PubMed search [3] [4]
Wikidata
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Interactions

PSKH1 is a regulated protein kinase with a defined substrate specificity, which has been shown to interact with (and be regulated by) proteins of the Cab45, reticulocalbin, Erc55, and calumenin family of calcium-binding proteins and calmodulin. It is also activated by UNC119B, an acyl chain binding protein.^[7] PSKH1 is closely related to the catalytically-inactive pseudokinase PSKH2, which is also membrane-localised within the secretory pathway.^[8]