PSME3

Proteasome activator complex subunit 3 is a protein encoded by the PSME3 gene in humans.^[5][6]

PSME3
Identifiers
Aliases	PSME3, HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA, proteasome activator subunit 3
External IDs	OMIM: 605129; MGI: 1096366; HomoloGene: 2111; GeneCards: PSME3; OMA:PSME3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 42,824,385 bp[1] End 42,843,760 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 64.67 cM Start 101,207,039 bp[2] End 101,214,363 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans monocyte stromal cell of endometrium rectum gastrocnemius muscle appendix mucosa of esophagus ganglionic eminence mucosa of transverse colon epithelium of colon Top expressed in blood tail of embryo ascending aorta yolk sac aortic valve genital tubercle epiblast ventricular zone spermatocyte seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function p53 binding MDM2/MDM4 family protein binding endopeptidase activator activity protein binding identical protein binding Cellular component membrane proteasome activator complex nucleoplasm proteasome complex nucleus cytoplasm cytosol Biological process regulation of proteasomal protein catabolic process regulation of cellular amino acid metabolic process antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent regulation of mRNA stability positive regulation of canonical Wnt signaling pathway negative regulation of extrinsic apoptotic signaling pathway protein polyubiquitination stimulatory C-type lectin receptor signaling pathway tumor necrosis factor-mediated signaling pathway MAPK cascade Fc-epsilon receptor signaling pathway regulation of G1/S transition of mitotic cell cycle NIK/NF-kappaB signaling cell cycle anaphase-promoting complex-dependent catabolic process T cell receptor signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of endopeptidase activity proteasome-mediated ubiquitin-dependent protein catabolic process apoptotic process Wnt signaling pathway, planar cell polarity pathway negative regulation of G2/M transition of mitotic cell cycle protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process transmembrane transport regulation of transcription from RNA polymerase II promoter in response to hypoxia post-translational protein modification regulation of hematopoietic stem cell differentiation interleukin-1-mediated signaling pathway regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10197 19192 Ensembl ENSG00000131467 ENSMUSG00000078652 UniProt P61289 P61290 RefSeq (mRNA) NM_001267045 NM_005789 NM_176863 NM_001330229 NM_011192 RefSeq (protein) NP_001253974 NP_001317158 NP_005780 NP_789839 NP_035322 Location (UCSC) Chr 17: 42.82 – 42.84 Mb Chr 11: 101.21 – 101.21 Mb PubMed search [3] [4]
Wikidata
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Function

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.^[6]

Interactions

PSME3 has been shown to interact with P53^[7] and Mdm2.^[7]