PSRC1

Proline/serine-rich coiled-coil protein 1 is a protein that in humans is encoded by the PSRC1 gene.^[5][6][7]

PSRC1
Identifiers
Aliases	PSRC1, DDA3, FP3214, proline and serine rich coiled-coil 1
External IDs	OMIM: 613126; MGI: 1913099; HomoloGene: 49603; GeneCards: PSRC1; OMA:PSRC1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,279,556 bp[1] End 109,283,186 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 108,291,155 bp[2] End 108,295,547 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment ventricular zone inferior olivary nucleus inferior ganglion of vagus nerve hippocampus proper right frontal lobe Brodmann area 9 substantia nigra anterior cingulate cortex primary visual cortex Top expressed in zygote secondary oocyte ventricular zone primary oocyte genital tubercle epiblast condyle calvaria maxillary prominence mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding microtubule binding Cellular component spindle microtubule cytoskeleton spindle cytosol microtubule cytoskeleton spindle pole midbody cytoplasm nucleoplasm Biological process mitotic metaphase plate congression negative regulation of cell growth microtubule bundle formation regulation of mitotic spindle organization cell division cell cycle cellular process or phenomenon positive regulation of transcription, DNA-templated positive regulation of microtubule polymerization positive regulation of cyclin-dependent protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84722 56742 Ensembl ENSG00000134222 ENSMUSG00000068744 UniProt Q6PGN9 Q5T2Z0 Q9D0P7 RefSeq (mRNA) NM_001005290 NM_001032290 NM_001032291 NM_032636 NM_001350237 NM_001350238 NM_001350239 NM_001350240 NM_001350241 NM_001350242 NM_001363309 NM_001394002 NM_001394003 NM_001394004 NM_001394005 NM_001190161 NM_019976 RefSeq (protein) NP_001005290 NP_001027462 NP_116025 NP_001337166 NP_001337167 NP_001337168 NP_001337169 NP_001337170 NP_001337171 NP_001350238 NP_001177090 NP_064360 Location (UCSC) Chr 1: 109.28 – 109.28 Mb Chr 3: 108.29 – 108.3 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]