MPGES-1

Microsomal prostaglandin E synthase-1 (mPGES-1)^[5][6] or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene.^[7][8][9]

PTGES
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DWW, 4WAB, 4AL1, 4BPM, 4YL1, 4YL3, 4YK5, 4AL0, 4YL0, 5BQI, 5BQG, 5BQH
Identifiers
Aliases	PTGES, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1, prostaglandin E synthase
External IDs	OMIM: 605172; MGI: 1927593; HomoloGene: 3587; GeneCards: PTGES; OMA:PTGES - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 129,738,331 bp[1] End 129,753,042 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 21.75 cM Start 30,779,483 bp[2] End 30,819,875 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva nasal epithelium gastric mucosa seminal vesicula cartilage tissue skin of leg mucosa of urinary bladder skin of abdomen nipple minor salivary glands Top expressed in blastocyst gastrula morula lactiferous gland decidua right kidney cumulus cell genital tubercle lumbar spinal ganglion granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutathione binding isomerase activity prostaglandin-E synthase activity glutathione transferase activity Cellular component cytoplasm integral component of membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle membrane nuclear envelope lumen perinuclear region of cytoplasm mitochondrion Biological process prostaglandin metabolic process response to cytokine response to organic cyclic compound response to retinoic acid lipid metabolism cyclooxygenase pathway fatty acid metabolic process response to calcium ion response to lipopolysaccharide fatty acid biosynthetic process acute inflammatory response prostaglandin biosynthetic process chronic inflammatory response negative regulation of cell population proliferation signal transduction glutathione metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9536 64292 Ensembl ENSG00000148344 ENSMUSG00000050737 UniProt O14684 Q9JM51 RefSeq (mRNA) NM_004878 NM_198797 NM_022415 RefSeq (protein) NP_004869 NP_071860 Location (UCSC) Chr 9: 129.74 – 129.75 Mb Chr 2: 30.78 – 30.82 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis.

Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.^[9]

It is inhibited by crisdesalazine (AAD-2004; GedaCure).^[10]

See also

• Prostaglandin E synthase