PTK6

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.^[5][6][7]

PTK6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RJA, 2KGT
Identifiers
Aliases	PTK6, BRK, protein tyrosine kinase 6
External IDs	OMIM: 602004; MGI: 99683; HomoloGene: 68494; GeneCards: PTK6; OMA:PTK6 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,528,001 bp[1] End 63,537,376 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 103.62 cM Start 180,835,514 bp[2] End 180,844,582 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon human penis skin of abdomen skin of leg mucosa of pharynx gums amniotic fluid gingival epithelium oral cavity jejunal mucosa Top expressed in jejunum esophagus lip intestinal villus blastocyst skin of external ear tongue ileum Ileal epithelium duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity non-membrane spanning protein tyrosine kinase activity kinase activity protein binding identical protein binding signaling receptor binding ATP binding protein tyrosine kinase activity Cellular component cytoplasm cell projection membrane ruffle extrinsic component of cytoplasmic side of plasma membrane nucleus nucleoplasm cytosol plasma membrane nuclear body Biological process cellular response to retinoic acid negative regulation of growth phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation negative regulation of protein tyrosine kinase activity regulation of cell population proliferation intestinal epithelial cell differentiation positive regulation of neuron projection development peptidyl-tyrosine autophosphorylation protein autophosphorylation innate immune response cell migration positive regulation of cell cycle ERBB2 signaling pathway negative regulation of signal transduction positive regulation of epidermal growth factor receptor signaling pathway tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5753 20459 Ensembl ENSG00000101213 ENSMUSG00000038751 UniProt Q13882 Q64434 RefSeq (mRNA) NM_001256358 NM_005975 NM_009184 NM_001356304 RefSeq (protein) NP_001243287 NP_005966 NP_033210 NP_001343233 Location (UCSC) Chr 20: 63.53 – 63.54 Mb Chr 2: 180.84 – 180.84 Mb PubMed search [3] [4]
Wikidata
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Function

Tyrosine-protein kinase 6—also known as BRK^[7] (breast tumor kinase)—is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.^[7]

Clinical significance

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.^[7]

Interactions

PTK6 has been shown to interact with STAP2^[8] and KHDRBS1.^[9]