PTP4A1

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.^[4][5]

PTP4A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RXD, 1XM2
Identifiers
Aliases	PTP4A1, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1, protein tyrosine phosphatase type IVA, member 1, protein tyrosine phosphatase 4A1
External IDs	OMIM: 601585; MGI: 1277096; HomoloGene: 2587; GeneCards: PTP4A1; OMA:PTP4A1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q12 Start 63,521,746 bp[1] End 63,583,436 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans muscle of thigh liver right lobe of liver rectum gastrocnemius muscle ganglionic eminence skeletal muscle tissue ventricular zone smooth muscle tissue n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein tyrosine phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity protein binding Cellular component cytoplasm endosome membrane plasma membrane spindle early endosome endoplasmic reticulum cytoplasmic side of plasma membrane cytoskeleton nucleus Biological process positive regulation of cell migration protein dephosphorylation multicellular organism development cell cycle dephosphorylation peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7803 19243 Ensembl ENSG00000112245 ENSMUSG00000026064 UniProt Q93096 Q63739 RefSeq (mRNA) NM_003463 NM_011200 RefSeq (protein) NP_003454 NP_035330 Location (UCSC) Chr 6: 63.52 – 63.58 Mb n/a PubMed search [2] [3]
Wikidata
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The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.^[5]

Interactions

PTP4A1 has been shown to interact with ATF7.^[6]