PTP4A2

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.^[5][6][7]

PTP4A2
Identifiers
Aliases	PTP4A2, HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b, protein tyrosine phosphatase type IVA, member 2, protein tyrosine phosphatase 4A2
External IDs	OMIM: 601584; MGI: 1277117; HomoloGene: 20744; GeneCards: PTP4A2; OMA:PTP4A2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 31,906,421 bp[1] End 31,944,856 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 129,705,012 bp[2] End 129,743,796 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum internal globus pallidus inferior ganglion of vagus nerve palpebral conjunctiva middle frontal gyrus optic nerve external globus pallidus parotid gland Medulla Oblongata ventral tegmental area Top expressed in tail of embryo extensor digitorum longus muscle triceps brachii muscle genital tubercle vastus lateralis muscle plantaris muscle muscle of thigh gastrocnemius muscle skeletal muscle tissue extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function prenylated protein tyrosine phosphatase activity protein tyrosine phosphatase activity phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein binding Cellular component cytoplasm endosome plasma membrane early endosome membrane nucleus cytosol Biological process protein dephosphorylation dephosphorylation peptidyl-tyrosine dephosphorylation post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8073 19244 Ensembl ENSG00000184007 ENSMUSG00000028788 UniProt Q12974 O70274 RefSeq (mRNA) NM_001195100 NM_001195101 NM_003479 NM_080391 NM_080392 NM_001369858 NM_001369859 NM_001369860 NM_001164745 NM_008974 RefSeq (protein) NP_001182029 NP_001182030 NP_536316 NP_001356787 NP_001356788 NP_001356789 NP_001158217 NP_033000 Location (UCSC) Chr 1: 31.91 – 31.94 Mb Chr 4: 129.71 – 129.74 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif.

This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity.

Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants that encode two distinct isoforms have been described.^[7]