PTP4A3

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.^[5]

PTP4A3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R6H, 1V3A, 2MBC
Identifiers
Aliases	PTP4A3, PRL-3, PRL-R, PRL3, protein tyrosine phosphatase type IVA, member 3, protein tyrosine phosphatase 4A3
External IDs	OMIM: 606449; MGI: 1277098; HomoloGene: 22500; GeneCards: PTP4A3; OMA:PTP4A3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 141,391,995 bp[1] End 141,432,454 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 73,594,994 bp[2] End 73,630,615 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gastric mucosa muscle of thigh left ventricle gastrocnemius muscle right auricle of heart skeletal muscle tissue anterior pituitary tibial arteries right coronary artery Top expressed in muscle of thigh extensor digitorum longus muscle blood plantaris muscle medial head of gastrocnemius muscle tibialis anterior muscle neural layer of retina digastric muscle knee joint triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity prenylated protein tyrosine phosphatase activity phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity protein binding Cellular component endosome plasma membrane early endosome membrane nucleus cytoplasm Biological process Notch signaling pathway protein dephosphorylation positive regulation of vascular permeability regulation of vascular endothelial growth factor signaling pathway endothelial cell migration dephosphorylation peptidyl-tyrosine dephosphorylation regulation of transcription, DNA-templated positive regulation of NIK/NF-kappaB signaling positive regulation of establishment of protein localization cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11156 19245 Ensembl ENSG00000184489 ENSG00000275575 ENSMUSG00000059895 UniProt O75365 Q9D658 RefSeq (mRNA) NM_007079 NM_032611 NM_001166388 NM_001166389 NM_001166390 NM_008975 NM_001357591 RefSeq (protein) NP_009010 NP_116000 NP_001159860 NP_001159861 NP_001159862 NP_033001 NP_001344520 Location (UCSC) Chr 8: 141.39 – 141.43 Mb Chr 15: 73.59 – 73.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.^[5]