PTPN12

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.^[5][6]

PTPN12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5J8R
Identifiers
Aliases	PTPN12, PTP-PEST, PTPG1, protein tyrosine phosphatase, non-receptor type 12, protein tyrosine phosphatase non-receptor type 12
External IDs	OMIM: 600079; MGI: 104673; HomoloGene: 37691; GeneCards: PTPN12; OMA:PTPN12 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 77,537,295 bp[1] End 77,640,069 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 20,986,645 bp[2] End 21,055,911 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad epithelium of colon monocyte right lung tibial nerve Achilles tendon lower lobe of lung upper lobe of lung upper lobe of left lung subcutaneous adipose tissue Top expressed in tail of embryo Gonadal ridge left lung lobe genital tubercle stroma of bone marrow trigeminal ganglion abdominal wall otic placode hair follicle dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding phosphatase activity protein binding hydrolase activity non-membrane spanning protein tyrosine phosphatase activity phosphoprotein phosphatase activity protein tyrosine phosphatase activity Cellular component podosome cell junction cell projection focal adhesion cytoplasm cytosol nucleoplasm Biological process tissue regeneration dephosphorylation protein dephosphorylation regulation of epidermal growth factor receptor signaling pathway peptidyl-tyrosine dephosphorylation cellular response to epidermal growth factor stimulus ERBB2 signaling pathway negative regulation of ERBB signaling pathway negative regulation of platelet-derived growth factor receptor-beta signaling pathway cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5782 19248 Ensembl ENSG00000127947 ENSMUSG00000028771 UniProt Q05209 P35831 RefSeq (mRNA) NM_001131008 NM_001131009 NM_002835 NM_011203 NM_001356590 NM_001356591 NM_001356592 RefSeq (protein) NP_001124480 NP_001124481 NP_002826 NP_035333 NP_001343519 NP_001343520 NP_001343521 Location (UCSC) Chr 7: 77.54 – 77.64 Mb Chr 5: 20.99 – 21.06 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein–protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.^[6]

Interactions

PTPN12 has been shown to interact with BCAR1,^{[7][8][9][10]} Grb2,^[11] PSTPIP1,^[12] TGFB1I1,^[13] Paxillin^[14][15][16] and SHC1.^[17][18]