PTPN13

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.^[5][6]

PTPN13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D5G, 1Q7X, 1WCH, 2M0Z, 2M10, 3LNX, 3LNY, 3PDZ
Identifiers
Aliases	PTPN13, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E, protein tyrosine phosphatase, non-receptor type 13, protein tyrosine phosphatase non-receptor type 13
External IDs	OMIM: 600267; MGI: 103293; HomoloGene: 7909; GeneCards: PTPN13; OMA:PTPN13 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.3 Start 86,594,315 bp[1] End 86,815,171 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E5|5 50.43 cM Start 103,573,058 bp[2] End 103,746,169 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus urethra human penis palpebral conjunctiva retinal pigment epithelium skin of arm renal medulla trigeminal ganglion gingival epithelium mucosa of pharynx Top expressed in corneal stroma hair follicle mucosa of urinary bladder transitional epithelium of urinary bladder retinal pigment epithelium medullary collecting duct skin of external ear conjunctival fornix skin of back sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity phosphatidylinositol 3-kinase regulatory subunit binding protein binding phosphoprotein phosphatase activity hydrolase activity Cellular component cytoplasm cell body neuron projection cell projection extracellular exosome cytoskeleton nucleus lamellipodium plasma membrane nucleoplasm Biological process protein dephosphorylation peptidyl-tyrosine dephosphorylation regulation of phosphatidylinositol 3-kinase signaling dephosphorylation phosphatidylinositol biosynthetic process negative regulation of protein phosphorylation cellular response to cytokine stimulus bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5783 19249 Ensembl ENSG00000163629 ENSMUSG00000034573 UniProt Q12923 Q64512 RefSeq (mRNA) NM_006264 NM_080683 NM_080684 NM_080685 NM_011204 RefSeq (protein) NP_006255 NP_542414 NP_542415 NP_542416 NP_035334 Location (UCSC) Chr 4: 86.59 – 86.82 Mb Chr 5: 103.57 – 103.75 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.^[6]

Interactions

PTPN13 has been shown to interact with PKN2.^[7]