PTPN14

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.^[5][6]

PTPN14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZL
Identifiers
Aliases	PTPN14, PEZ, PTP36, protein tyrosine phosphatase, non-receptor type 14, CATLPH, protein tyrosine phosphatase non-receptor type 14, PTPD2
External IDs	OMIM: 603155; MGI: 102467; HomoloGene: 3941; GeneCards: PTPN14; OMA:PTPN14 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3-q41 Start 214,348,700 bp[1] End 214,552,449 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H6|1 95.03 cM Start 189,460,465 bp[2] End 189,608,892 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell parietal pleura tibia skin of thigh skin of hip Skeletal muscle tissue of rectus abdominis visceral pleura Skeletal muscle tissue of biceps brachii nipple germinal epithelium Top expressed in endothelial cell of lymphatic vessel tail of embryo vestibular membrane of cochlear duct skin of external ear genital tubercle epithelium of lens condyle stroma of bone marrow lip epidermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity hydrolase activity phosphatase activity receptor tyrosine kinase binding transcription coregulator activity protein binding protein tyrosine phosphatase activity Cellular component nucleus cytoplasm cytoskeleton nucleoplasm Biological process negative regulation of cell population proliferation regulation of transcription, DNA-templated protein dephosphorylation regulation of protein export from nucleus transcription, DNA-templated dephosphorylation lymphangiogenesis peptidyl-tyrosine dephosphorylation cellular response to cytokine stimulus regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5784 19250 Ensembl ENSG00000152104 ENSMUSG00000026604 UniProt Q15678 Q62130 RefSeq (mRNA) NM_005401 NM_001033287 NM_008976 RefSeq (protein) NP_005392 NP_033002 Location (UCSC) Chr 1: 214.35 – 214.55 Mb Chr 1: 189.46 – 189.61 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.^[6]

Interactions

PTPN14 has been shown to interact with Beta-catenin.^[7]