PTPN18

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.^[5][6]

PTPN18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OC3, 4GFU, 4GFV, 4NND
Identifiers
Aliases	PTPN18, BDP1, PTP-HSCF, protein tyrosine phosphatase, non-receptor type 18, protein tyrosine phosphatase non-receptor type 18
External IDs	OMIM: 606587; MGI: 108410; HomoloGene: 74971; GeneCards: PTPN18; OMA:PTPN18 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q21.1 Start 130,356,045 bp[1] End 130,375,405 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 B|1 13.25 cM Start 34,498,843 bp[2] End 34,514,814 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte right uterine tube mucosa of transverse colon rectum cerebellar hemisphere right hemisphere of cerebellum spleen tendon of biceps brachii body of pancreas Top expressed in granulocyte thymus blood spleen mesenteric lymph nodes submandibular gland tibiofemoral joint duodenum lacrimal gland primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding non-membrane spanning protein tyrosine phosphatase activity phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine phosphatase activity Cellular component nucleus cytoplasm cytosol nucleoplasm Biological process protein dephosphorylation peptidyl-tyrosine dephosphorylation dephosphorylation ERBB2 signaling pathway negative regulation of ERBB signaling pathway cellular response to cytokine stimulus blastocyst formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26469 19253 Ensembl ENSG00000072135 ENSMUSG00000026126 UniProt Q99952 Q61152 RefSeq (mRNA) NM_001142370 NM_014369 NM_011206 RefSeq (protein) NP_001135842 NP_055184 NP_035336 Location (UCSC) Chr 2: 130.36 – 130.38 Mb Chr 1: 34.5 – 34.51 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological function of this PTP has not yet been determined.^[6]

Interactions

PTPN18 has been shown to interact with PSTPIP1.^[7]