PTPN21

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.^[5][6]

PTPN21
Identifiers
Aliases	PTPN21, PTPD1, PTPRL10, protein tyrosine phosphatase, non-receptor type 21, protein tyrosine phosphatase non-receptor type 21
External IDs	OMIM: 603271; MGI: 1344406; HomoloGene: 5110; GeneCards: PTPN21; OMA:PTPN21 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q31.3 Start 88,465,778 bp[1] End 88,555,007 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 98,643,000 bp[2] End 98,703,664 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh secondary oocyte skin of hip lower lobe of lung skin of abdomen right lung right ventricle lactiferous duct left testis right testis Top expressed in zygote secondary oocyte primary oocyte neural layer of retina medial head of gastrocnemius muscle sciatic nerve extraocular muscle muscle of thigh cardiac muscles internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity hydrolase activity phosphatase activity protein binding protein tyrosine phosphatase activity Cellular component cytoplasm cytoskeleton Biological process protein dephosphorylation dephosphorylation peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11099 24000 Ensembl ENSG00000070778 ENSMUSG00000021009 UniProt Q16825 Q62136 RefSeq (mRNA) NM_007039 NM_001146199 NM_011877 RefSeq (protein) NP_008970 n/a Location (UCSC) Chr 14: 88.47 – 88.56 Mb Chr 12: 98.64 – 98.7 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.^[6]

Interactions

PTPN21 has been shown to interact with BMX^[7] and KIF1C.^[8]