PTPN23

Tyrosine-protein phosphatase non-receptor type 23 is an enzyme that in humans is encoded by the PTPN23 gene.^[5][6]

PTPN23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RAU, 5CRV, 5CRU
Identifiers
Aliases	PTPN23, HD-PTP, HDPTP, PTP-TD14, protein tyrosine phosphatase, non-receptor type 23, protein tyrosine phosphatase non-receptor type 23, NEDBASS
External IDs	OMIM: 606584; MGI: 2144837; HomoloGene: 135706; GeneCards: PTPN23; OMA:PTPN23 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 47,381,011 bp[1] End 47,413,435 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 110,214,150 bp[2] End 110,237,281 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve pituitary gland skin of arm anterior pituitary right hemisphere of cerebellum right lobe of thyroid gland stromal cell of endometrium left lobe of thyroid gland gastrocnemius muscle canal of the cervix Top expressed in internal carotid artery ventricular zone external carotid artery yolk sac granulocyte neural layer of retina superior frontal gyrus tail of embryo primary visual cortex genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity protein kinase binding hydrolase activity Cellular component cytoplasm ciliary basal body endosome cell projection cilium nucleoplasm early endosome extracellular exosome cytoskeleton cytoplasmic vesicle nucleus nuclear body cytosol Biological process positive regulation of homophilic cell adhesion cilium assembly regulation of cell migration protein dephosphorylation positive regulation of adherens junction organization cell projection organization protein transport positive regulation of early endosome to late endosome transport ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway negative regulation of epithelial cell migration dephosphorylation peptidyl-tyrosine dephosphorylation early endosome to late endosome transport positive regulation of Wnt protein secretion transport endocytic recycling cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25930 104831 Ensembl ENSG00000076201 ENSMUSG00000036057 UniProt Q9H3S7 Q6PB44 RefSeq (mRNA) NM_001304482 NM_015466 NM_001081043 RefSeq (protein) NP_001291411 NP_056281 NP_001074512 Location (UCSC) Chr 3: 47.38 – 47.41 Mb Chr 9: 110.21 – 110.24 Mb PubMed search [3] [4]
Wikidata
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