PTPN9

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.^[5][6]

PTPN9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PA5, 4GE2, 4GE5, 4GE6, 4ICZ
Identifiers
Aliases	PTPN9, MEG2, PTPMEG2, protein tyrosine phosphatase, non-receptor type 9, protein tyrosine phosphatase non-receptor type 9
External IDs	OMIM: 600768; MGI: 1928376; HomoloGene: 2121; GeneCards: PTPN9; OMA:PTPN9 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.2 Start 75,463,251 bp[1] End 75,579,315 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 56,902,207 bp[2] End 56,970,091 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence stromal cell of endometrium right lobe of thyroid gland left lobe of thyroid gland tibial nerve monocyte hair follicle islet of Langerhans rectum Top expressed in entorhinal cortex perirhinal cortex lactiferous gland choroid plexus of fourth ventricle Ileal epithelium CA3 field corneal stroma maxillary prominence Gonadal ridge mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphoprotein phosphatase activity hydrolase activity non-membrane spanning protein tyrosine phosphatase activity phosphatase activity protein binding Cellular component cytoplasm nucleoplasm neuron projection terminus Biological process protein dephosphorylation dephosphorylation cellular response to cytokine stimulus negative regulation of neuron projection development peptidyl-tyrosine dephosphorylation positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5780 56294 Ensembl ENSG00000169410 ENSMUSG00000032290 UniProt P43378 O35239 RefSeq (mRNA) NM_002833 NM_019651 RefSeq (protein) NP_002824 NP_062625 Location (UCSC) Chr 15: 75.46 – 75.58 Mb Chr 9: 56.9 – 56.97 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by poly-phosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.^[6]