PTPRF

Receptor-type tyrosine-protein phosphatase F is an enzyme that, in humans, is encoded by the PTPRF gene.^[5][6]

PTPRF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LAR, 2DJU, 2EDX, 2EDY, 2YD5, 2YD8, 4N5U, 2DN7
Identifiers
Aliases	PTPRF, LAR, BNAH2, protein tyrosine phosphatase, receptor type F, protein tyrosine phosphatase receptor type F
External IDs	OMIM: 179590; MGI: 102695; HomoloGene: 20623; GeneCards: PTPRF; OMA:PTPRF - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 43,525,187 bp[1] End 43,623,666 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.1 Start 118,208,213 bp[2] End 118,291,405 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium bronchial epithelial cell nipple parotid gland hair follicle germinal epithelium jejunal mucosa skin of arm skin of thigh epithelium of nasopharynx Top expressed in medullary collecting duct epithelium of lens transitional epithelium of urinary bladder hair follicle vestibular sensory epithelium vestibular membrane of cochlear duct external carotid artery conjunctival fornix left lung left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chondroitin sulfate proteoglycan binding heparin binding phosphoprotein phosphatase activity phosphatase activity protein-containing complex binding protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity hydrolase activity cell adhesion molecule binding Cellular component integral component of membrane membrane integral component of plasma membrane soma neuron projection extracellular exosome plasma membrane Biological process neuron projection regeneration regulation of axon regeneration negative regulation of receptor binding regulation of neuron projection development protein dephosphorylation transmembrane receptor protein tyrosine phosphatase signaling pathway cell adhesion peptidyl-tyrosine dephosphorylation cell migration dephosphorylation synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5792 19268 Ensembl ENSG00000142949 ENSMUSG00000033295 UniProt P10586 A2A8L5 RefSeq (mRNA) NM_002840 NM_130440 NM_001329137 NM_001329138 NM_001329139 NM_001329140 NM_011213 RefSeq (protein) NP_001316066 NP_001316067 NP_001316068 NP_001316069 NP_002831 NP_569707 NP_035343 Location (UCSC) Chr 1: 43.53 – 43.62 Mb Chr 4: 118.21 – 118.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig-like domains similar to those of the neural cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.^[6]

Interactions

PTPRF has been shown to interact with Beta-catenin^[7][8] and liprin-alpha-1.^[9][10][11]