PTPRG

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.^[4][5]

PTPRG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H4V, 2HY3, 2NLK, 2PBN, 3JXH, 3QCB, 3QCC, 3QCD, 3QCE, 3QCF, 3QCG, 3QCH, 3QCI, 3QCJ, 3QCK, 3QCL, 3QCM, 3QCN
Identifiers
Aliases	PTPRG, HPTPG, PTPG, R-PTP-GAMMA, RPTPG, protein tyrosine phosphatase, receptor type G, protein tyrosine phosphatase receptor type G
External IDs	OMIM: 176886; MGI: 97814; HomoloGene: 2129; GeneCards: PTPRG; OMA:PTPRG - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.2 Start 61,561,569 bp[1] End 62,297,609 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon lower lobe of lung caput epididymis synovial joint buccal mucosa cell oocyte pericardium corpus epididymis urethra stromal cell of endometrium n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity identical protein binding Cellular component integral component of membrane integral component of plasma membrane extracellular exosome membrane extracellular space Biological process regulation of homophilic cell adhesion protein dephosphorylation negative regulation of epithelial cell migration transmembrane receptor protein tyrosine kinase signaling pathway dephosphorylation brain development negative regulation of neuron projection development peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5793 19270 Ensembl ENSG00000144724 n/a UniProt P23470 Q05909 RefSeq (mRNA) NM_002841 NM_001375471 NM_008981 NM_001347593 RefSeq (protein) NP_002832 NP_001362400 NP_001334522 NP_033007 Location (UCSC) Chr 3: 61.56 – 62.3 Mb n/a PubMed search [2] [3]
Wikidata
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.^[5]