PURB

For the concept in cryptography, see PURB (cryptography).

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.^[5][6]

PURB
Identifiers
Aliases	PURB, PURBETA, purine-rich element binding protein B, purine rich element binding protein B
External IDs	OMIM: 608887; MGI: 1338779; HomoloGene: 69087; GeneCards: PURB; OMA:PURB - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,876,299 bp[1] End 44,885,530 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 4.16 cM Start 6,417,599 bp[2] End 6,425,917 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm cerebellar vermis pancreatic epithelial cell gingival epithelium pancreatic ductal cell visceral pleura Brodmann area 23 tibialis anterior muscle epithelium of nasopharynx myocardium of left ventricle Top expressed in lateral septal nucleus anterior amygdaloid area Region I of hippocampus proper primary motor cortex piriform cortex olfactory tubercle cingulate gyrus superior colliculus lateral geniculate nucleus subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding double-stranded DNA binding SMAD binding single-stranded DNA binding transcription factor binding mRNA binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific purine-rich negative regulatory element binding sequence-specific DNA binding Cellular component DNA replication factor A complex nucleus Biological process regulation of myeloid cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II cell population proliferation cell differentiation transcription, DNA-templated negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5814 19291 Ensembl ENSG00000146676 ENSMUSG00000094483 UniProt Q96QR8 O35295 RefSeq (mRNA) NM_033224 NM_011221 RefSeq (protein) NP_150093 NP_035351 Location (UCSC) Chr 7: 44.88 – 44.89 Mb Chr 11: 6.42 – 6.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.

Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.^[6]