Peptide transporter 1

Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene.^[5][6] PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.^[7]

SLC15A1
Identifiers
Aliases	SLC15A1, HPECT1, HPEPT1, PEPT1, Peptide transporter 1, solute carrier family 15 member 1
External IDs	OMIM: 600544; MGI: 1861376; HomoloGene: 38006; GeneCards: SLC15A1; OMA:SLC15A1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q32.2-q32.3 Start 98,683,801 bp[1] End 98,752,672 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E5 Start 121,697,033 bp[2] End 121,742,664 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum jejunal mucosa mucosa of ileum gallbladder vulva skin of abdomen skin of arm skin of thigh right lobe of liver human penis Top expressed in epithelium of small intestine intestinal villus jejunum left colon duodenum ileum esophagus lip skin of external ear skin of back More reference expression data BioGPS More reference expression data
Gene ontology Molecular function proton-dependent oligopeptide secondary active transmembrane transporter activity symporter activity transporter activity transmembrane transporter activity oligopeptide transmembrane transporter activity peptide:proton symporter activity dipeptide transmembrane transporter activity peptide transmembrane transporter activity Cellular component integral component of membrane plasma membrane brush border membrane integral component of plasma membrane Biological process protein transport peptide transport oligopeptide transport oligopeptide transmembrane transport ion transport transmembrane transport proton transmembrane transport dipeptide transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6564 56643 Ensembl ENSG00000088386 ENSMUSG00000025557 UniProt P46059 Q9JIP7 RefSeq (mRNA) NM_005073 NM_053079 RefSeq (protein) NP_005064 NP_444309 Location (UCSC) Chr 13: 98.68 – 98.75 Mb Chr 14: 121.7 – 121.74 Mb PubMed search [3] [4]
Wikidata
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PepT 1 is a proton-coupled peptide cotransporter in epithelial cells.

Function

SLC15A1is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.^[5][7] Peptide transporter 1 functions in nutrient and drug transport have been studied using intestinal organoids.^[8][9]

See also

• Solute carrier family