Peroxiredoxin 2

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.^[5][6]

PRDX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QMV
Identifiers
Aliases	PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
External IDs	OMIM: 600538; MGI: 109486; HomoloGene: 21182; GeneCards: PRDX2; OMA:PRDX2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,796,820 bp[1] End 12,801,800 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C3|8 41.4 cM Start 85,696,216 bp[2] End 85,701,463 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus trabecular bone pars compacta pars reticulata external globus pallidus Pons right ventricle apex of heart right adrenal cortex left adrenal gland Top expressed in ventricular zone embryo dentate gyrus of hippocampal formation granule cell embryo right kidney superior frontal gyrus lip yolk sac muscle of thigh neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity antioxidant activity peroxiredoxin activity peroxidase activity protein binding thioredoxin peroxidase activity Cellular component cytoplasm extracellular exosome cytosol Biological process regulation of apoptotic process negative regulation of apoptotic process hydrogen peroxide catabolic process cell redox homeostasis response to oxidative stress cellular response to oxidative stress removal of superoxide radicals respiratory burst involved in inflammatory response regulation of hydrogen peroxide metabolic process positive regulation of blood coagulation negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity response to lipopolysaccharide T cell proliferation hydrogen peroxide metabolic process negative regulation of T cell differentiation thymus development homeostasis of number of cells negative regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand leukocyte activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7001 21672 Ensembl ENSG00000167815 ENSMUSG00000005161 UniProt P32119 Q61171 RefSeq (mRNA) NM_181738 NM_005809 NM_181737 NM_011563 NM_001317385 RefSeq (protein) NP_005800 NP_001304314 NP_035693 Location (UCSC) Chr 19: 12.8 – 12.8 Mb Chr 8: 85.7 – 85.7 Mb PubMed search [3] [4]
Wikidata
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PRDX2 encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 0.27 nm (= 2.7 angstroms). Transcript variants encoding distinct isoforms have been identified for this gene.^[6]