Phospholipase A-2-activating protein

Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene.^[5][6][7]

PLAA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K89, 2K8A, 2K8B, 2K8C, 3EBB
Identifiers
Aliases	PLAA, DOA1, PLA2P, PLAP, phospholipase A2 activating protein, NDMSBA
External IDs	OMIM: 603873; MGI: 104810; HomoloGene: 3138; GeneCards: PLAA; OMA:PLAA - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.2 Start 26,903,372 bp[1] End 26,947,242 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C5|4 43.34 cM Start 94,455,751 bp[2] End 94,491,481 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle secondary oocyte stromal cell of endometrium muscle of thigh testicle ganglionic eminence monocyte ventricular zone gonad Achilles tendon Top expressed in tail of embryo genital tubercle zygote secondary oocyte epiblast medial ganglionic eminence Gonadal ridge mandibular prominence primitive streak somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phospholipase A2 activator activity ubiquitin binding Cellular component extracellular exosome cytoplasm nucleus synapse cell junction Biological process phospholipid metabolic process inflammatory response signal transduction ubiquitin recycling proteasome-mediated ubiquitin-dependent protein catabolic process macroautophagy ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway cellular response to lipopolysaccharide negative regulation of protein K63-linked ubiquitination positive regulation of synaptic vesicle recycling positive regulation of dendrite extension positive regulation of neuron migration prostaglandin metabolic process multicellular organism development nervous system development positive regulation of phospholipase A2 activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9373 18786 Ensembl ENSG00000137055 ENSMUSG00000028577 UniProt Q9Y263 P27612 RefSeq (mRNA) NM_001031689 NM_004253 NM_001321546 NM_172695 RefSeq (protein) NP_001026859 NP_001308475 NP_766283 Location (UCSC) Chr 9: 26.9 – 26.95 Mb Chr 4: 94.46 – 94.49 Mb PubMed search [3] [4]
Wikidata
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