Phospholipase A2 group IVD

Phospholipase A2 group IVD is a protein that in humans is encoded by the PLA2G4D gene. ^[5]

PLA2G4D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IXC, 5IZR, 5IZ5
Identifiers
Aliases	PLA2G4D, cPLA2delta, phospholipase A2 group IVD
External IDs	OMIM: 612864; MGI: 1925640; HomoloGene: 52252; GeneCards: PLA2G4D; OMA:PLA2G4D - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 42,067,009 bp[1] End 42,094,562 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 120,096,076 bp[2] End 120,119,678 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg gonad testicle vagina pituitary gland anterior pituitary prostate ectocervix endometrium Top expressed in esophagus primary oocyte placenta secondary oocyte decidua spermatid embryo lumbar subsegment of spinal cord zygote seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function phospholipase activity metal ion binding hydrolase activity phospholipase A1 activity lysophospholipase activity phospholipase A2 activity calcium-dependent phospholipase A2 activity calcium ion binding calcium-dependent phospholipid binding Cellular component cytoplasm cytosol membrane Biological process phosphatidic acid biosynthetic process phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process phosphatidylglycerol acyl-chain remodeling phospholipid catabolic process phospholipid metabolic process metabolism phosphatidylcholine acyl-chain remodeling glycerophospholipid catabolic process fatty acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283748 78390 Ensembl ENSG00000159337 ENSMUSG00000070719 UniProt Q86XP0 Q50L43 RefSeq (mRNA) NM_178034 NM_001024137 RefSeq (protein) NP_828848 NP_001019308 Location (UCSC) Chr 15: 42.07 – 42.09 Mb Chr 2: 120.1 – 120.12 Mb PubMed search [3] [4]
Wikidata
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Function

The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids.^[6]