Phosphomevalonate kinase

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway^[5][6][7] that in humans is encoded by the PMVK gene.

Mevalonate pathway

PMVK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CH4
Identifiers
Aliases	PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase
External IDs	OMIM: 607622; MGI: 1915853; HomoloGene: 4779; GeneCards: PMVK; OMA:PMVK - orthologs
EC number	2.7.4.2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 154,924,740 bp[1] End 154,936,719 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 89,361,848 bp[2] End 89,376,320 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lobe of liver anterior pituitary nucleus accumbens C1 segment skin of abdomen anterior cingulate cortex skin of leg right adrenal cortex right auricle of heart Top expressed in fossa lip condyle motor neuron facial motor nucleus trigeminal ganglion ectoderm otic placode supraoptic nucleus otic vesicle More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding ATP binding kinase activity phosphomevalonate kinase activity Cellular component cytoplasm cytosol peroxisome extracellular exosome membrane Biological process cholesterol biosynthetic process steroid metabolic process isopentenyl diphosphate biosynthetic process, mevalonate pathway response to cholesterol cholesterol metabolic process sterol biosynthetic process isoprenoid biosynthetic process phosphorylation lipid metabolism steroid biosynthetic process regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10654 68603 Ensembl ENSG00000163344 ENSMUSG00000027952 UniProt Q15126 Q9D1G2 RefSeq (mRNA) NM_006556 NM_001323011 NM_001323012 NM_001348696 NM_026784 NM_027348 NM_001310640 RefSeq (protein) NP_001309940 NP_001309941 NP_006547 NP_001335625 NP_001297569 NP_081060 NP_081624 Location (UCSC) Chr 1: 154.92 – 154.94 Mb Chr 3: 89.36 – 89.38 Mb PubMed search [3] [4]
Wikidata
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Phosphomevalonate kinase
Identifiers
EC no.	2.7.4.2
CAS no.	9026-46-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Phosphomevalonate kinase
Identifiers
Symbol	PMVK
NCBI gene	10654
HGNC	9141
OMIM	607622
RefSeq	NM_006556
UniProt	Q15126
Other data
EC number	2.7.4.2
Locus	Chr. 1 p13-q23
Search for Structures Swiss-model Domains InterPro